abstract：:From kinetic analysis on the initial stage of the fibrinogen-fibrin conversion catalyzed by thrombin, inhibition constants, Kip, of heparin and heparin analogues were obtained by the turbidimetrical method. The inhibitory effect per unit amount in weight of heparin and heparin analogues increased generally with decrea...

journal_title：Thrombosis research

authors： Sato H,Nakajima A,Shimohira T

更新日期：1985-09-01 00:00:00

abstract：:The action of AD6 as an anti-thrombotic agent was studied in a model of coronary artery thrombosis and on platelet aggregation in the dog. AD6 (10-100 microM) in vitro inhibited aggregation induced by ADP, epinephrine, collagen and PAF (platelet aggregating factor) used at their threshold concentration for maximal agg...

journal_title：Thrombosis research

authors： Prosdocimi M,Finesso M,Tessari F,Gorio A,Languino LR,de Gaetano G,Dejana E

更新日期：1985-08-15 00:00:00

abstract：:Mice were implanted subcutaneously with a pellet containing 0.5 mg estradiol or with a placebo. Eight to 12 days later platelet aggregation was produced in mesenteric arterioles by injuring their endothelium in vivo with a noxious light/dye stimulus. The time between the onset of the noxious stimulus and the appearanc...

journal_title：Thrombosis research

authors： Rosenblum WI,el-Sabban F,Allen AD,Nelson GH,Bhatnagar AS,Choi S

更新日期：1985-08-01 00:00:00

abstract：:The effects of sodium salicylate (SS) on ADP-induced platelet aggregation and on a metabolism of calcium in platelets were studied, using gel-filtrated platelets (GFP). SS inhibited dose-responsively ADP-induced aggregation in the presence of fibrinogen and Ca2+. It was found that extracellular 45Ca2+ was rapidly take...

journal_title：Thrombosis research

authors： Irino O,Saitoh K,Ohkubo K,Hashimoto S

更新日期：1985-08-01 00:00:00

abstract：:Two isozymes of a native form of human plasminogen (plg), Glu-plg I and II, were isolated. Glu-plg I or II was activated by urokinase (UK) or streptokinase (SK) in the presence of fibrinogen or fibrin. The activation of Glu-plg I was enhanced more than that of Glu-plg II in the presence of fibrin. Fibrin caused better...

journal_title：Thrombosis research

authors： Takada Y,Makino Y,Takada A

更新日期：1985-08-01 00:00:00

abstract：:This study comprised 50 patients subjected to major abdominal surgery, of which 13 developed deep vein thrombosis (DVT) according to the 125I-fibrinogen test. Plasma was sampled preoperatively, for the specific analysis of tissue plasminogen activator (t-PA) before and during venous occlusion. The recently described f...

journal_title：Thrombosis research

authors： Mellbring G,Dahlgren S,Wiman B,Sunnegårdh O

更新日期：1985-07-15 00:00:00

abstract：:In 51 shock patients with DIC Antithrombin III (AT III) substitution, heparin or a combination of both substances respectively was administered. In the two groups which had been given AT III substitution the concentration of AT III rose considerably higher than the activity. There was a drop of the platelet count in b...

journal_title：Thrombosis research

authors： Blauhut B,Kramar H,Vinazzer H,Bergmann H

更新日期：1985-07-01 00:00:00

abstract：:Danazol, a synthetic androgen reported to increase factor VIII and IX activity levels, was given to 6 hemophiliacs. With danazol therapy (600 mg/da) the APTTs shortened by 30-45% of pre-treatment times. However, the activity levels of the deficient factors did not increase significantly nor consistently with the APTT ...

journal_title：Thrombosis research

authors： Garewal HS,Corrigan JJ Jr,Jeter MA,Damiano ML,Durie BG

更新日期：1985-07-01 00:00:00

abstract：:Incubation of platelets with pronase or chymotrypsin results in the exposure of fibrinogen receptors. We determined that these enzymes did not affect the membrane fluidity as evaluated by the depolarization of the fluorescence of 1,6-diphenyl-1,3,5 hexatriene (DPH). There was no significant difference in either the de...

journal_title：Thrombosis research

authors： Simons E,Whitin JC,Morinelli TA,Stewart GJ,Niewiarowski S

更新日期：1985-07-01 00:00:00

abstract：:Platelet membrane glycoprotein V (GPV) was hydrolyzed during thrombin-induced platelet aggregation releasing a fragment GPVfl into the supernatant. Hydrolysis of GPV required catalytically active thrombin and was diminished by chemical modification of the fibrinogen binding site of thrombin. Half-maximal liberation of...

journal_title：Thrombosis research

authors： White GC 2nd,Knupp CL

更新日期：1985-06-15 00:00:00

abstract：:We investigated on how to effectively administer orally factor VIII preparation to two patients with von Willebrand's disease as volunteers, and the following results were obtained: Bleeding time and aPTT were shortened, but no change of PT was observed. Factor VIII:C increased slightly, but no significant increase wa...

journal_title：Thrombosis research

authors： Sakuragawa N,Niiya K,Kondo S

更新日期：1985-06-15 00:00:00

abstract：:Activation of human plasminogen by human tissue-type plasminogen activator (t-PA) is accelerated in the presence of cyanogen bromide digests of human fibrin(ogen). In the present study a possible species specificity of this phenomenon was investigated. All combinations of the plasminogens, fibrin monomers and cyanogen...

journal_title：Thrombosis research

authors： Nieuwenhuizen W,Keyser J

更新日期：1985-06-15 00:00:00

abstract：:1 g acetyl salicylic acid orally significantly enhanced the initial rate of platelet aggregation induced by 1 mumol/l and 2.5 mumol/l ADP. Sodium salicylate was without effects on the platelet aggregation and specifically it did not prevent acetylsalicylic acid from inhibiting the secondary aggregation. Sodium salicyl...

journal_title：Thrombosis research

authors： Ring T,Dyerberg J

更新日期：1985-06-15 00:00:00

abstract：:A rapid method is described for the production of a human marrow cell suspension highly enriched in megakaryocytes. These concentrates were incubated with radiolabelled amino-acids, and cell lysates were then analysed for fibrinogen synthesis. Neosynthesized proteins were detected by immunoprecipitation, immuno-affini...

journal_title：Thrombosis research

authors： Belloc F,Hourdille P,Fialon P,Boisseau MR,Soria J

更新日期：1985-05-15 00:00:00

abstract：:The influence of red blood cells on platelet aggregation has recently been a subject of considerable interest. We have studied the effect of red cells on spontaneously formed platelet aggregates in rotating vials at 37 degrees C. Platelet aggregation was quantified by measuring the fall in number of single platelets w...

journal_title：Thrombosis research

authors： Saniabadi AR,Lowe GD,Barbenel JC,Forbes CD

更新日期：1985-05-01 00:00:00

abstract：:Antithrombin III (AT III) is increased in situations where there is increased platelet turnover. Plasma AT III levels measured in 39 renal transplant recipients were significantly higher than in 20 healthy subjects (p less than 0.001) and 20 patient controls (p less than 0.025). AT III levels were significantly correl...

journal_title：Thrombosis research

authors： Woo KT,Lee EJ,Lau YK,Lim CH

更新日期：1985-05-01 00:00:00

abstract：:Contact angle measurements, histological examinations and platelet adhesion tests on native and glutaraldehyde-treated porcine aortic valve leaflets, are reported. Contact angles measured with water or saline on native and treated leaflets do not differ appreciably. Values of less than 10 degrees for both the dry and ...

journal_title：Thrombosis research

authors： Hum OS,Ghista DN,Brash JL

更新日期：1985-04-15 00:00:00

abstract：:Addition of two commercial luciferin-luciferase reagents caused marked inhibition of the aggregatory response of washed human platelets to thrombin, ADP, vasopressin and platelet-activating factor (PAF). Analysis of the effects of the individual components of one of these reagents revealed that Mg2+, and to a lesser e...

journal_title：Thrombosis research

authors： Thompson NT,Scrutton MC

更新日期：1985-04-15 00:00:00

abstract：:We investigated the effects of Defibrotide (D), a natural polydeoxyribonucleotide, on acute myocardial ischemia (AMI) in anesthetized cats. A permanent ligature was placed around the left anterior descending coronary artery (LAD) 12-14 mm from its origin. Ventricular fibrillation and death were exceptional and when th...

journal_title：Thrombosis research

authors： Niada R,Porta R,Pescador R,Mantovani M,Prino G

更新日期：1985-04-01 00:00:00

abstract：:The presence of Factor XIII subunit a was demonstrated in human monocytes by immunoperoxidase staining using specific antisera against Factor XIII and its subunits. This finding was verified by immunobiochemical techniques, as well. In an immunoblotting system after SDS polyacrylamide gel electrophoresis of denatured ...

journal_title：Thrombosis research

authors： Muszbek L,Adány R,Szegedi G,Polgár J,Kávai M

更新日期：1985-02-01 00:00:00

abstract：:Platelet prothrombin converting activity was measured in a system using washed human platelets and purified coagulation factors Xa, Va and prothrombin. Exposure of platelet prothrombin converting activity evoked by collagen or the combined action of collagen and thrombin was effectively inhibited when a collagen deriv...

journal_title：Thrombosis research

authors： Bevers EM,Karniguian A,Legrand YJ,Zwaal RF

更新日期：1985-02-01 00:00:00

abstract：:The effect of several vitamin K (Vit K) analogues on the aggregation of human platelets was examined. The analogues were potent inhibitors of aggregation induced by ADP, thrombin, collagen and arachidonate but were less active against aggregation induced by the calcium ionophore A23187. Vit K3 also prevented platelet ...

journal_title：Thrombosis research

authors： Blackwell GJ,Radomski M,Moncada S

更新日期：1985-01-01 00:00:00

abstract：:Ticlopidine (100 mg/kg/day or 400 mg/kg/day) was administered to rats and rabbits for 48 hr before and during the experiments. Aggregation studies of twice-washed platelets resuspended in Tyrode solution containing apyrase and 0.35% albumin showed that inhibition by ticlopidine of aggregation induced by ADP, collagen,...

journal_title：Thrombosis research

authors： Cattaneo M,Winocour PD,Somers DA,Groves HM,Kinlough-Rathbone RL,Packham MA,Mustard JF

更新日期：1985-01-01 00:00:00

abstract：:The role of Protein C in combined factor V/VIII deficiency was examined by reducing the Protein C concentration using warfarin therapy in a patient with the combined deficiency. The factor VIII deficiency was like Hemophilia-A, with deficiency of VIII:C and VIII:C(Ag), but normal VIIIR:Ag and VIIIR:cof. The factor V d...

journal_title：Thrombosis research

authors： Bern MM,Suzuki K,Mann K,Tracy P,Hoyer L,Jensen W,Gallivan M,Arkin C,Davis G

更新日期：1984-12-15 00:00:00

abstract：:In-vitro determinations of purified kallikrein on the one hand, of human plasma and whole blood prekallikrein on the other hand have been conducted with the S-2648 electrogenic substrate using the electroanalytical technique. Plasmatic evaluations have been checked photometrically for assessing the reliability of the ...

journal_title：Thrombosis research

authors： Corretge E,Nigretto JM

更新日期：1984-12-15 00:00:00

abstract：:Capsaicin was found to be a potent inhibitor of platelet aggregation and release reaction. It inhibited the aggregation of rat platelet induced by collagen and thrombin, but only slightly reduced those of AA and A23187. The IC50 on collagen-induced platelet aggregation was about 85 micrograms/ml. Less inhibition was o...

journal_title：Thrombosis research

authors： Wang JP,Hsu MF,Teng CM

更新日期：1984-12-15 00:00:00

abstract：:Thirty-four derivatives of benzamidine were tested for their inhibitory activities on bovine and human thrombins using the chromogenic peptide substrate N-D-Phe-Pip-Arg-pNA. The inhibition constants of small molecular size inhibitors of comparatively low affinity as well as those of tight binding inhibitors did not di...

journal_title：Thrombosis research

authors： Stürzebecher J,Walsmann P,Voigt B,Wagner G

更新日期：1984-12-01 00:00:00

abstract：:The hemodynamic and antithrombotic action of ZK 36374, a stable carbacyclin derivative of prostacyclin, was studied during electrically-induced coronary artery thrombosis in the open chest anesthetized pig. Infusion of ZK 36374 (100 ng/kg/min, n = 6) had no effect on heart rate and cardiac output, but caused a 20% red...

journal_title：Thrombosis research

authors： van der Giessen WJ,Mooi WJ,Rutteman AM,Berk L,Verdouw PD

更新日期：1984-10-01 00:00:00

abstract：:Using high-resolution real-time two-dimensional ultrasound, we have investigated the role of red cells in the growth of already established platelet aggregates under controlled flow conditions. Platelet rich plasma (PRP) was circulated in vitro in horizontally and vertically arranged tubing at mean shear rate ranging ...

journal_title：Thrombosis research

authors： Machi J,Sigel B,Ramos JR,Justin JR,Feinberg H,LeBreton GC,Robertson AL Jr

更新日期：1984-10-01 00:00:00

abstract：:Bleeding is an important complication of heparin therapy. A number of low molecular weight heparin fractions produce less bleeding than standard heparin for an equivalent antithrombotic effect in experimental animals. Low molecular weight heparin fractions and fragments are produced by a number of different procedures...

journal_title：Thrombosis research

authors： Cade JF,Buchanan MR,Boneu B,Ockelford P,Cater CJ,Cerskus AL,Hirsh J

更新日期：1984-09-15 00:00:00

abstract：:Activation of washed platelets in the presence of EDTA with either 1 U/ml of alpha-thrombin or 2 microM calcium ionophore (A23187) caused the release of one-third to one-half of the platelet factor VIII/von Willebrand factor (FVIII/vWF) into the supernatant. When calcium was present in excess, only 10% of the platelet...

journal_title：Thrombosis research

authors： Furby FH,Berndt MC,Castaldi PA,Koutts J

更新日期：1984-09-01 00:00:00

abstract：:Seven males with atherosclerotic disease received daily 1.6 g of the thromboxane antagonist BM 13.177 in two separate oral dosages over a period of four days. The drug significantly reduced elevated plasma levels of thromboxane B2, beta-thromboglobulin and platelet factor 4, whereas thromboxane B2 generation was only ...

journal_title：Thrombosis research

authors： Riess H,Hiller E,Reinhardt B,Bräuning C

更新日期：1984-08-15 00:00:00

abstract：:The sequel of survivors after hospitalisation for an acute myocardial infarction was studied during the following 15 years in 48 patients treated with streptokinase and in 41 controls. No significant difference was seen in the morbidity or mortality during the first 6 months nor in the mortality thereafter. ...

journal_title：Thrombosis research

authors： Heikinheimo R,Leskinen O,Siitonen L

更新日期：1984-08-15 00:00:00

abstract：:The effect of suloctidil (600 mg/day) on platelet survival time (PST) and plasma and urine betathromboglobulin (BTG) was studied in a double-blind, placebo-controlled six-week crossover trial in 13 patients with shortened PST (less than 110 hrs, exponential model). Mean PST after suloctidil (110.6 hrs) was significant...

journal_title：Thrombosis research

authors： Turpie AG,Gent M,deBoer AC,Giroux M,Kinch D,Butt R,Gunstensen J,Saerens E,Genton E

更新日期：1984-08-15 00:00:00

abstract：:The fibrinolytic potential of tissue-type plasminogen activator (t-PA) either incorporated in a clot (endogenous) or added to the surrounding plasma (exogenous), was studied in an in vitro system consisting of 125I-labeled human plasma clots (200 microliters) immersed in human plasma (2 ml). Clot lysis was measured as...

journal_title：Thrombosis research

authors： Zamarron C,Lijnen HR,Collen D

更新日期：1984-08-01 00:00:00

abstract：:Three collagenases were purified from the culture medium of human skin fibroblasts using ammonium sulfate fractionation, ion-exchange chromatography and gel filtration. The cationic collagenase had a molecular weight of 42,000; two anionic collagenases had molecular weights of 63,000 and 115,000. Preincubation of the ...

journal_title：Thrombosis research

authors： Pisoni R,Ciaglowski RE,Brown RK,Walz DA

更新日期：1984-07-15 00:00:00

abstract：:A prolongation of the thrombin clotting time by at least 25% was found in the presence of 8 of 26 IgG myeloma proteins, 2 of 5 IgA proteins and 1 of 10 macroglobulins, in a concentration of 10 mg/ml. Normal pooled immunoglobulin in concentrations up to 83 mg/ml were inactive. 2 IgG and 2 IgM monoclonal immunoglobulins...

journal_title：Thrombosis research

authors： Wisløff F,Michaelsen TE,Godal HC

更新日期：1984-07-01 00:00:00

abstract：:The inhibitory effects of several antiinflammatory agents on the specific binding of tritiated 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphorylcholine, (platelet activating factor, PAF), with its receptor on isolated rabbit platelet plasma membranes were investigated. Several potent cyclooxygenase inhibitors do not inhibi...

journal_title：Thrombosis research

authors： Hwang SB,Cheah MJ,Lee CS,Shen TY

更新日期：1984-06-15 00:00:00

abstract：:The heparin-binding properties of human plasma apolipoproteins B-100 and E (apoB-100 and E) of low density lipoproteins (LDL), thrombin, and antithrombin-III (AT-III) were investigated. A highly reactive heparin (HRH) to apoB-100 was isolated by chromatography of crude heparin on a column of LDL immobilized to Affi-Ge...

journal_title：Thrombosis research

authors： Cardin AD,Barnhart RL,Witt KR,Jackson RL

更新日期：1984-06-15 00:00:00

abstract：:Four calcium channel blockers (nimodipine, nifedipine, verapamil and diltiazem) of three chemical classes were tested in vitro for inhibition of platelet aggregation using heparinized human platelet rich plasma. Both ADP- and thrombin-induced aggregation were inhibited as was the biosynthesis of thromboxane A2 in resp...

journal_title：Thrombosis research

authors： Onoda JM,Sloane BF,Honn KV

更新日期：1984-06-01 00:00:00